Effect of Glutamine on Urinary Incontinence

Istanbul University

Status: Completed

Conditions: Urinary Incontinence

Treatments: Dietary Supplement: glutamine supplementation; Dietary Supplement: fantomalt supplementation

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03265509

2014/1203

Details and patient eligibility

About

The objective of this study is to determine to effect of additional oral glutamine to Kegel exercises on pelvic floor strength and clinical parameters of urinary incontinence in females with either urinary incontinence (stress and/or urgency) and pelvic prolapse.

Full description

Urinary incontinence is a prevalent and costly condition that affects approximately 38% of older community-dwelling women (age>60 years). Incontinence predisposes patients to other health problems, contributes to depression and social isolation, is a significant source of dependency among the elderly, and is widely cited as a factor in nursing home admissions. Sarcopenia is age-related and is characterized by loss of muscle mass, strength and endurance. There is not only a decrease in the number of muscle fibers, but also atrophy in the remaining ones. Several studies indicate glutamine supplementations lead to better muscle performance by stimulate muscle producing in extremities. Similarly, we assume glutamine supplementation could increase pelvic muscle mass and improve the pelvic floor strength. From this point, using glutamine supplementation may effect positively on stress, urge or mixed incontinence, and pelvic prolapse.

Enrollment: 50 patients

Sex: Female

Ages: 45 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of urinary incontinence and/or pelvic prolapse and/or decreased vaginal muscle strength in gynaecological examination

Exclusion criteria

• Uncontrolled diabetes
• Cognitive dysfunction hampering participation in exercise or assessment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Glutamine

Active Comparator group

Description:

30 g/day Glutamine supplementation for three months

Treatment:

Dietary Supplement: glutamine supplementation

Fantomalt

Placebo Comparator group

Description:

30 g/day Fantomalt supplementation for three months

Treatment:

Dietary Supplement: fantomalt supplementation