Effect of Glutaraldehyde on Dentin Hypersensitivity After Non-surgical Periodontal Treatment

Universidade Federal do Para

Status: Completed

Conditions: Dentin Sensitivity

Treatments: Other: Placebo Gel + 5% Glutaraldehyde Aqueous Solution; Other: Placebo gel; Other: Phosphoric Acid 37% + Solução aquosa de glutaraldeído a 5%

Study type: Interventional

Funder types: Other

Identifiers

NCT04207450

UFPara-006

Details and patient eligibility

About

This randomized, placebo-controlled, triple-blind trial aims to evaluate the effect of glutaraldehyde associated or not with 37% phosphoric acid conditioning on dentin hypersensitivity reduction after non-surgical periodontal treatment, and its durability after 15 and 30 days. desensitizing treatment. Additionally, investigate the impact of these treatments on health-related quality of life. The investigators selected patients who, after scraping and planing procedures, presented at least 2 teeth meeting the following inclusion criteria: presence of gingival recession without or with a periodontal pocket up to 5mm probing depth, which presented painful sensitivity response to tactile stimulus. and evaporative. Subjects were randomized into 3 groups: Placebo Group (GP) - Placebo Gel application followed by Placebo solution (distilled water); GPG- Placebo Gel application followed by application 5% aqueous glutaraldehyde solution; GSG - Application of 37% phosphoric acid followed by 5% aqueous glutaraldehyde solution. The sensitivity of the dental elements was evaluated by pain stimuli (tactile and evaporative) with the aid of a Visual Analog Scale (VAS). A questionnaire was applied to patients with the objective of capturing psychosocial experiences, prior to treatment and one month after its completion, to assess the impact of desensitizing treatment on health-related quality of life. Data will be collected and appropriate statistical tests will be applied.

Enrollment: 40 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Presence of gingival recession without or with periodontal pocket up to 5mm probing depth, which presented painful sensitivity response to tactile and evaporative stimuli.

Exclusion criteria

• Systemic diseases;
• Pulpitis;
• Carious lesions;
• Presence of restorations in selected teeth;
• Cracked enamel;
• Noncarious cervical lesions;
• Use of medication with analgesics and/or anti-inflammatories;
• Pregnant or lactating women;
• Desensitizing treatment and periodontal treatment received during three months prior to study recruitment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 3 patient groups, including a placebo group

Placebo Group

Placebo Comparator group

Description:

Placebo Gel + Placebo Solution (Distilled Water)

Treatment:

Other: Placebo gel

Placebo Gel + Glutaraldehyde (GPG)

Experimental group

Description:

Placebo Gel + 5% Glutaraldehyde Aqueous Solution

Treatment:

Other: Placebo Gel + 5% Glutaraldehyde Aqueous Solution

Phosphoric Acid + Glutaraldehyde (GAG)

Experimental group

Description:

37% Phosphoric Acid + Glutaraldehyde Aqueous Solution (GAG)

Treatment:

Other: Phosphoric Acid 37% + Solução aquosa de glutaraldeído a 5%