Effect of Glycopyrrolate and Atropine on Catheter-Related Bladder Discomfort

Seoul National University

Status: Unknown

Conditions: Catheter Site Discomfort; Urinary Bladder Neoplasms; Complications; Anesthesia

Treatments: Drug: Glycopyrrolate; Drug: Atropine

Study type: Interventional

Funder types: Other

Identifiers

NCT02228473

CRBDGlycoAtr

Details and patient eligibility

About

We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.

Full description

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The adjuncts to reversal agents such as glycopyrrolate and atropine are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.

Enrollment: 76 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for transurethral bladder excision under general anesthesia
• ASA I-III

Exclusion criteria

• Foley catheter less than 18 Fr.
• Patients with obstruction of urinary tract
• Patients with neurogenic bladder
• Patients with severe obesity
• Patients with neurologic disorder
• Patients with chronic pain
• Patients with allergic history to atropine or glycopyrrolate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

76 participants in 2 patient groups

Glycopyrrolate

Experimental group

Description:

Glycopyrrolate will be administered as the adjuncts of neuromuscular blocker reversal agent.

Treatment:

Drug: Glycopyrrolate

Atropine

Active Comparator group

Description:

Atropine will be administered as the adjuncts of neuromuscular blocker reversal agent.

Treatment:

Drug: Atropine