Effect of Goal-directed Fluid Therapy on Postoperative Complications

Seoul National University

Status: Completed

Conditions: Pancreas Disease; Liver Diseases

Treatments: Device: EV1000 platform

Study type: Observational

Funder types: Other

Identifiers

NCT03169998

EV1000

Details and patient eligibility

About

• It has been known that the recent application of a goal-directed fluid therapy (GDFT) to the intraoperative fluid infusion in patients contributes to decreasing the prevalence of postoperative complications and shortening the length of study in the intensive care unit as well as hospital stay compared with conventional methods.
• Laparoscopic surgery is in a trend that its application is being expanded recently, but there has been no report on the application of GDFT to laparoscopic surgery so far.
• To this end, this study aims to apply the intraoperative GDFT protocol in patients undergoing laparoscopic hepatobiliary or pancreatic surgery and to find out whether there is any difference in postoperative recovery and incidences of postoperative complications, by comparing with patients applied with the fluid therapy using existing conventional methods

Enrollment: 375 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Laparoscopic hepatobiliary or pancreatic surgery

Exclusion criteria

• Patients who do not consent to participation in the study
• Pregnant women, breastfeeding women

Trial design

375 participants in 2 patient groups

GDFT group

Description:

The fluid infusion is to be performed, in accordance with GDFT protocol, on the basis of cardiac index (CI), stroke volume index(SVI) and stroke volume (SV) in addition to invasively measured arterial pressure by Vigilio / FloTrac Monitor.

Treatment:

Device: EV1000 platform

Control group

Description:

Patients in whom the surgery was conducted without the use of EV1000/ FloTrac monitoring among those who had undergone laparoscopic hepatobiliary or pancreatic surgery in the past.