Effect of Granisetron on Usage of Sympathomimetics During Caesarean Section

Johann Wolfgang Goethe University Hospital

Status: Completed

Conditions: Hypotension; Cesarean Section Complications

Treatments: Drug: No Granisetron; Drug: Granisetron Hydrochloride

Study type: Observational

Funder types: Other

Identifiers

NCT03318536

XXX/17

Details and patient eligibility

About

The aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.

Full description

Recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically.

Due to this fact in our clinic the standard procedure was changed. All patients for caesarean section receive Granisetron before spinal anesthesia.

The aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia.

Therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.

Enrollment: 240 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• caesarean section in spinal anesthesia

Exclusion criteria

• withdrawal
• incomplete documentation

Trial design

240 participants in 2 patient groups

No Granisetron

Description:

120 Patients prior to changes of intern standards of caesarean section. Before march 2017 no patient undergoing elective caesarean section received Granisetron as a matter of routine.

Treatment:

Drug: No Granisetron

With Granisetron

Description:

120 Patients after changes of intern standards of caesarean section. After march 2017 all patient undergoing elective caesarean section received Granisetron as a matter of routine.

Treatment:

Drug: Granisetron Hydrochloride