Effect of Growth Hormone (GH) on Cardiac Echos in GH Deficient Patients After Acromegaly Treatment

Mass General Brigham

Status: Completed

Conditions: Acromegaly

Study type: Observational

Funder types: Other

Identifiers

NCT01302652

2010P002188

Details and patient eligibility

About

The purpose of this research study is to study the effects of growth hormone (GH) replacement on the heart. The investigators will study these effects in people who have been cured of acromegaly and then have developed growth hormone deficiency (GHD, not enough growth hormone).

Enrollment: 20 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-75
• history of acromegaly with biochemical cure
• growth hormone deficiency

Exclusion criteria

• untreated thyroid disease within the past 3 months
• untreated adrenal insufficiency within the past 3 months
• uncontrolled hypertension
• congestive heart failure
• gonadal steroid therapy within the past 3 months
• pregnancy or nursing

Trial design

20 participants in 2 patient groups

GH deficient after acromegaly cure (on GH replacement)

Description:

Men and women with growth hormone deficiency following cure of acromegaly who are receiving growth hormone treatment.

GH deficient after acromegaly cure (not on GH replacement)

Description:

Men and women with growth hormone deficiency following cure of acromegaly who are not receiving growth hormone treatment.