Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

University of Aarhus

Status: Completed

Conditions: Insulin Resistance

Treatments: Device: Physiological Bolus of Growth Hormone

Study type: Interventional

Funder types: Other

Identifiers

NCT00477997

MM-GH-20070052

Details and patient eligibility

About

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Enrollment: 8 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Healthy
• Age between 18 and 30 years
• BMI ≤ 26

Exclusion criteria

• Known present disease including diabetes mellitus
• BMI > 26
• Uses any medication
• Consumes > 21 units of alcohol per week

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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8 participants in 3 patient groups, including a placebo group

1

Placebo Comparator group

Description:

Saline bolus + OGTT

Treatment:

Device: Physiological Bolus of Growth Hormone

2

Other group

Description:

GH-bolus and OGTT

Treatment:

Device: Physiological Bolus of Growth Hormone

3

Other group

Description:

GH-bolus

Treatment:

Device: Physiological Bolus of Growth Hormone