Effect of Gualou Xiebai Banxia Decoction With Danshen Decoction in Treating Unstable Angina.

Jun Li

Status and phase: Unknown; Phase 4

Conditions: Unstable Angina

Treatments: Drug: Gualou Xiebai Banxia Decoction & Danshen Decoction; Drug: Coronary Vasodilator; Drug: Lipid Regulating Drugs; Drug: Anti-Platelet Drugs

Study type: Interventional

Funder types: Other

Identifiers

NCT03179514

GLXB-2017

Details and patient eligibility

About

This study evaluates the clinical efficacy of Gualou Xiebai Banxia Decoction compounded with Danshen Decoction in the treatment of unstable angina pectoris. All of the patients will be divided into 2 arms randomly. One of the arms will be treated by conventional western medicine, the other one will be treated by Gualou Xiebai Banxia Decoction compounded with Danshen Decoction at the base of conventional western medicine.

Full description

Gualou Xiebai Banxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type.

Enrollment: 120 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants diagnosed with coronary heart disease through coronary angiography or coronary CTA;

Patients have at least one of these symptoms:

1. The stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration;
2. Angina pectoris during rest;
3. The recent occurrence of angina pectoris caused by mild physical activity in the last month.

Exclusion criteria

• Patients diagnosed with stable angina; Patients with acute myocardial infarction; Chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; The heart function grade is III or IV; Patients with acute cerebral infarction; Patients complicated with other serious primary diseases; Patients with acute infection in recent 2 weeks; Uncontrolled hypertension (the resting blood pressure >160/95mmHg within one week); Diabetics emerged with serious diabetic complications; Patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; Pregnant or lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Phlegm and blood stasis

Experimental group

Description:

Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.

Treatment:

Drug: Coronary Vasodilator

Drug: Anti-Platelet Drugs

Drug: Gualou Xiebai Banxia Decoction & Danshen Decoction

Drug: Lipid Regulating Drugs

Conventional western medicine

Other group

Description:

Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc.

Treatment:

Drug: Coronary Vasodilator

Drug: Anti-Platelet Drugs

Drug: Lipid Regulating Drugs