Effect of Gynostemma Pentaphyllum Tea in Insulin Sensitivity in Type 2 Diabetic Patients

Hanoi Medical University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: Placebo tea; Dietary Supplement: Gynostemma Pentaphyllum tea

Study type: Interventional

Funder types: Other

Identifiers

NCT01254084

Diabetes II-Study3

Study 3

Details and patient eligibility

About

The aim of the present study was to investigate the effects of Gynostemma Pentaphyllum tea on insulin sensitivity in drug-naïve type 2 diabetic patients.

Full description

In Vietnam, traditional herbal medicines have played a major role in the management of diabetes for centuries. Gynostemma Pentaphyllum (GP) Makino (Family Cucurbitaceae) is a perennial creeping herb growing wild in the mountainous regions of Vietnam, China and some other Asian countries and was widely used in Southeast Asian countries as an herbal medicine and being beneficial for the prevention and treatment of diabetes. We have previously published the evidences that GP tea possessed anti-diabetic effect with good safety data in newly diagnosed T2D patients, and had effect on insulin sensitivity. In addition extract of GP had been shown to reduce both hyperglycemia and hyperlipidemia in diabetic Zucker Fatty rats. So the present study was to investigate the effects of Gynostemma Pentaphyllum tea in insulin sensitivity in type 2 diabetic patients.

Enrollment: 16 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnosed, drug-naive patients with type 2 diabetes
• Fasting plasma glucose: 7-11 mmol/l
• HbA1C: 7-9%.

Exclusion criteria

• Type 1 diabetes
• Liver and kidney failure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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16 participants in 2 patient groups, including a placebo group

Placebo tea

Placebo Comparator group

Description:

Dietary Supplement: Placebo tea 3 gram twice daily, orally

Treatment:

Dietary Supplement: Placebo tea

Gynostemma pentaphyllum Tea

Active Comparator group

Description:

Gynostemma Pentaphyllum tea 3 grams twice daily, orally

Treatment:

Dietary Supplement: Gynostemma Pentaphyllum tea