Effect of Haemodialysis on the Efficacy of Antiplatelet Agents

N

Nanjing Medical University

Status

Unknown

Conditions

Hemolysis
Coronary Artery Disease
Renal Failure

Treatments

Device: Clopidogrel group;Ticagrelor group

Study type

Observational

Funder types

Other

Identifiers

NCT03330223
008

Details and patient eligibility

About

The main purpose of our study is to investigate whether haemodialysis itself affects the efficacy of antiplatelet drugs and the effects of two different types of dialysis membranes (polysulfone membranes and polyamide membranes) on antiplatelet efficacy. A total of 60 patients with ESRD and under dual-antiplatelet treatmen for at least 5 days will be enrolled and divided into the Clopidogrel group (clopidogrel 75mg qd;aspirin 100mg qd, n=30) and the Ticagrelor group (ticagrelor 90mg bid; aspirin 100mg qd, n=30). All included patients will receive haemodialysis by two different types of dialysis membrane.Platelet aggregation of venous blood from all patients will be detected by LTA and VerifyNow immediately before and after two times of haemodialysis.

Enrollment

60 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • diagnosis of coronary heart disease including stable angina, unstable angina, acute myocardial infarction
  • taking dual antiplatelet drugs (clopidogrel 75mg qd + aspirin 100mg qd or ticagrelor 90 mg,bid + aspirin 100 mg,qd) at least 5 days
  • haemodialysis patients
  • sign informed consent

Exclusion criteria

  • platelet count>450 × 10 9 /L or <100 × 10 9 /L
  • using IIb / IIIa inhibitor drugs within 10days
  • taking nonsteroidal anti-inflammatory drugs other than aspirin
  • hemorrhagic disease
  • allergic to aspirin, ticagrelor or clopidogrel
  • other factors may affect the results of this study

Trial design

60 participants in 2 patient groups

Clopidogrel
Description:
clopidogrel 75mg qd;aspirin 100mg qd, n=30
Treatment:
Device: Clopidogrel group;Ticagrelor group
Ticagrelor
Description:
ticagrelor 90mg bid; aspirin 100mg qd, n=30
Treatment:
Device: Clopidogrel group;Ticagrelor group

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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