Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis

Tanta University

Status and phase: Not yet enrolling; Phase 3; Phase 2

Conditions: Effective Intracanal Medicaments Against Enterococcus Faecalis

Treatments: Drug: Ibuprofen 400 mg.; Dietary Supplement: curcumin; Dietary Supplement: olive leaves extract; Drug: modified triple antibiotic paste

Study type: Interventional

Funder types: Other

Identifiers

NCT06006663

eliminations of E.faecalis

Details and patient eligibility

About

this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Full description

we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .

samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.

bacterial reduction will be determined and comparision will be made .

Enrollment: 32 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Single rooted teeth.
• Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
• Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.

Exclusion criteria

• • Teeth with fractures of the crown or root.

  • Teeth with periodontal pocket deeper than 4mm.
  • Teeth have procedural error like ledge, broken instrument, or perforation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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32 participants in 4 patient groups

group 1

Active Comparator group

Description:

ibuprofen as intracanal medicament

Treatment:

Drug: Ibuprofen 400 mg.

group 2

Active Comparator group

Description:

modified triple antibiotic paste as intracanal medicament

Treatment:

Drug: modified triple antibiotic paste

group 3

Active Comparator group

Description:

curcumin as intracanal medicament

Treatment:

Dietary Supplement: curcumin

group 4

Active Comparator group

Description:

olive leaves as intracanal medicament

Treatment:

Dietary Supplement: olive leaves extract