Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects (AFC-SPICES)

Lund University

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Herbs 2; Dietary Supplement: Spices 1; Dietary Supplement: Herbs 1; Dietary Supplement: Spices 3; Dietary Supplement: Spices 2; Dietary Supplement: Control drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02035241

LUND-AFC-STAGE3-SPICES

Details and patient eligibility

About

The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite ratings (VAS-visual analogue scales) in healthy volunteers. We hypothesize that certain herbs and spices added to a standardized meal will improve postprandial glucose tolerance and other metabolic biomarkers in healthy volunteers, compared with a similar meal without the corresponding plant materials.

Full description

The aims of the study is to investigate whether consumption of preload isovolumetric (220 ml) spice-based beverages contained total polyphenol concentration to 185 mg gallic-acid equivalents followed by white wheat bread challenge (contained 50 g available carbohydrate) might affect postprandial glucose metabolism, inflammatory markers, appetite-related gut hormones, plasma antioxidant capacity, as well as appetite sensations in healthy subjects.

Enrollment: 21 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males and females
• Signed informed consent
• BMI 20 - 28 kg/m2 with weight change <3 kg latest 2 months)
• Must be able to accept herbs and spices

Exclusion criteria

• Below 18 years
• Uncomfortable speaking English and/or difficulties in understanding spoken English
• Smoking or using snuff
• Vegetarian or vegan
• Stressed by venous blood sampling or previous experience of being difficult to cannulate
• Receiving any drug treatment that may influence the study outcomes
• Pregnancy or breastfeeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 6 patient groups, including a placebo group

Spices 1

Experimental group

Description:

220 ml test drink containing spices 1, acute study / one time administration

Treatment:

Dietary Supplement: Spices 1

Spices 2

Experimental group

Description:

220 ml test drink containing spices 2, acute study / one time administration

Treatment:

Dietary Supplement: Spices 2

Spices 3

Experimental group

Description:

220 ml test drink containing spices 3, acute study / one time administration

Treatment:

Dietary Supplement: Spices 3

Herbs 1

Experimental group

Description:

220 ml test drink containing herbs 1, acute study / one time administration

Treatment:

Dietary Supplement: Herbs 1

Herbs 2

Experimental group

Description:

220 ml test drink containing herbs 2, acute study / one time administration

Treatment:

Dietary Supplement: Herbs 2

Placebo

Placebo Comparator group

Description:

220 ml control drink, acute study / one time administration

Treatment:

Dietary Supplement: Control drink