Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
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About
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
Full description
Baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the ALMA base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
Enrollment
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Volunteers
Inclusion criteria
- Born, raised and currently living <800m
- No overnight stay at altitudes >1500 m 4 weeks before the study
Exclusion criteria
- Previous altitude intolerance to altitude <3000 m
- Pregnancy
- Health impairment, which requires regular treatment
Trial design
Primary purpose
Allocation
Interventional model
Masking
21 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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