Effect of High Altitude Exposure, Acclimatization and Re-exposure on Lung Water Content by Ultrasound

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Effect of High Altitude

Treatments

Procedure: Altitude Exposure

Study type

Interventional

Funder types

Other

Identifiers

NCT02760186
REB15-2709_V5

Details and patient eligibility

About

Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude.

Full description

Low altitude baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the Atacama large Millimeter Array (ALMA) base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 7 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing physiological testing. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 7 day altitude sojourn participants will return to the Santiago area (520 m) for a 7 day recovery period. A second altitude sojourn cycle with an identical schedule as the one described above and a final low altitude stay of 3 days will follow. Measurements on study subjects will be performed at baseline (lowland, Santiago de Chile), then at 2nd day of altitude exposure and 7th day at altitude before returning to lowland; those are repeated in the second altitude sojourn cycle. Measurements will be conducted by qualified specialists using a portable ultrasound device.

Enrollment

21 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Born, raised and currently living <800m
  • No overnight stay at altitudes > 1500m 4 weeks before the study

Exclusion criteria

  • Previous altitude intolerance to altitude <3000m
  • Pregnancy
  • Health impairment, which requires regular treatment

Trial design

Primary purpose

Prevention

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

21 participants in 1 patient group

Altitude Exposure
Experimental group
Description:
Acute high altitude exposure followed by 7 day acclimatization and reexposure after 7 days at low altitude
Treatment:
Procedure: Altitude Exposure

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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