Effect of High Caloric Diet on Brain Insulin Sensitivity and Inflammation

University Hospital Tuebingen

Status: Completed

Conditions: Obesity; Diabetes Mellitus, Type 2

Treatments: Other: High caloric diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03590561

813/2017BO2

Details and patient eligibility

About

Obesity if known to be associated with brain insulin resistance in humans and evidence is rapidly accumulating that brain insulin resistance influences peripheral metabolism, eating behavior and cognition. A reduced insulin response in the brain is found mainly in people with a metabolically unfavorable fat distribution - high visceral fat. Visceral fat produces inflammatory mediators and elevated inflammatory levels are closely linked to insulin resistance. Inflammation of the brain (i.e., neuroinflammation) has been proposed as a possible cause of brain insulin resistance. Interestingly, rodent models of a high calorie diet show that these inflammatory mechanisms occur rapidly in the brain, even prior to weight gain of the animals. Among other things, it has been shown in humans that a short-term increase in calories, especially carbohydrates and fats, reduces insulin sensitivity in the body and increases inflammatory parameters in the blood. Whether a high-calorie diet triggers insulin resistance or inflammation in the human brain is currently unknown.

Aim of study:

The aim of the study is to investigate the effects of a five-day high calorie diet in healthy young male volunteers on peripheral and brain insulin sensitivity as well as on eating behavior, mood and cognition. Brain insulin sensitivity, peripheral metabolism and different behavioral assessments will be evaluated before, 1 week and 2 weeks after high caloric diet.

Enrollment: 32 patients

Sex: Male

Ages: 18 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 19-24 kg/m2

  • Non smoking
  • normal glucose tolerance during 75g oral glucose tolerance test (OGTT)
  • Exercise less than 2h per week

Exclusion criteria

• Vegetarians and Vegans
• Food allergies
• Working at night
• Professional Athletes
• Not removable metal parts in or on the body
• manifest cardiovascular disease
• claustrophobia
• recent surgery (less than 3 months)
• Simultaneous participation in other studies
• Acute disease or infection within the last 4 weeks
• neurological and psychiatric disorders
• treatment with centrally acting drugs
• hemoglobin Hb <13g / dl
• Hypersensitivity to any of the substances used

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

High caloric diet

Experimental group

Description:

Participants will eat 1500 kcal more than their usual diet for five days.

Treatment:

Other: High caloric diet

Control diet

No Intervention group

Description:

Participants will eat regular diet.