Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients

Deraya University

Status: Enrolling

Conditions: Hypertension; Arterial Stiffness

Treatments: Dietary Supplement: DASH diet; Procedure: High Intensity Interval Training

Study type: Interventional

Funder types: Other

Identifiers

NCT07188272

September 2025

Details and patient eligibility

About

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients

Enrollment: 20 estimated patients

Sex: All

Ages: 35 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Their age< 35 up to 50 years old
• Both sexes.
• Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
• Hemodynamic stable. Able to provide informed consent

Exclusion criteria

• Uncontrolled hypertension.
• Severe HTN <180/110 mmhg
• Renal dysfunction
• Unstable cardiac conditions
• Severe pulmonary disease that limit exercise
• Impaired cognition
• Musculoskeletal problems that made it difficult to do exercise

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

DASH diet group

Experimental group

Description:

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT) combined with DASH diet.

Treatment:

Dietary Supplement: DASH diet

Comparator group

Active Comparator group

Description:

22 patients will receive hypotensive drugs and High Intensity Interval Training ( HIIT)

Treatment:

Procedure: High Intensity Interval Training