Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure (DIISCCO)

Anil Nigam

Status: Unknown

Conditions: Hypertension,Essential; Exercise Activity

Treatments: Other: 24h-Ambulatory Blood Pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT04103411

2018-2319

Details and patient eligibility

About

The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.

Enrollment: 60 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age at consent ≥ 60 years;
2. Systolic Blood pressure measured through BPtru™ between SBP ≥ 120 mmHg and < 140 and or DBP ≥ 80 mmHg
3. Being able to sign the informed consent form

Exclusion criteria

1. Considered "highly active" according to the International Physical Activity Questionnaire
2. Practicing more than 20 min per week of High-Intensity Interval Training
3. Use of antihypertensive medication
4. Contraindication for the practice of intense physical activity
5. Functional limitations related to the exercise test and to intensive training
6. Cardiovascular pathology
7. Atrial fibrillation
8. Psychiatric or neurological disorder
9. Renal failure
10. MMSE score < 26
11. Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations.
12. Diabetes

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

High Intensity Interval Training (HIIT)

Experimental group

Description:

For the twelve weeks of intervention, participants will have three training sessions per week. Each session will be done on a cycle ergometer and will last approximately 40 minutes. Participants will be supervised by certified kinesiologists and their training programs will be revised every four weeks.

Treatment:

Other: 24h-Ambulatory Blood Pressure

HydroChloroThiazide

Active Comparator group

Description:

For this group, participants have to take a diuretic (12,5 mg of Hydrochlorothiazide) daily prescribed by the doctor of this study, for twelve weeks. Participants should also maintain the same lifestyle habits that they had before the study.

Treatment:

Other: 24h-Ambulatory Blood Pressure