Effect of High-intensity Low-volume Training on Insulin Sensitivity in Type 2 Diabetes (HIT)

German Diabetes Center

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Other: High intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT02039934

HIT and insulin sensitivity

Details and patient eligibility

About

High intensity interval training is applied for several diseases.

Hypothesis: High intensity interval training improves insulin sensitivity in patients with type 2 diabetes.

Full description

Type 2 diabetes mellitus is a multifactorial metabolic disease that is characterized by reduced insulin sensitivity and insulin production leading to impaired glucose tolerance. Overweight and low physical activity are the main risk factors for the development of type 2 diabetes. Increased physical activity has shown to improve insulin sensitivity, hence, exercise plays a significant role in the prevention and therapy of type 2 diabetes. This study aims at investigating the acute and chronic effects of high-intensity low-volume training, that consists of brief bursts of very vigorous exercise separated by recovery periods, on metabolic function in patients with type 2 diabetes, people at high risk for the disease and healthy, lean individuals. Study participants take part in 30 min training session three times a week for a period of 12 weeks. Participants are studied on four occasions, prior to the intervention, after an acute bout of exercise as well as after 6 and 12 weeks of training in order to assess physical fitness, body composition, insulin sensitivity, energy metabolism in muscle, adipose tissue inflammation and neurological function. It is hypothesized that this type of exercise leads to significant improvements in insulin action and oxidative phosphorylation in muscle

Enrollment: 60 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women
• Age: 30 - 65 years
• Typ-2-Diabetes (BMI > 25 kg/m²)
• Increased risk for diabetes (BMI >25 kg/m²)

Exclusion criteria

• Acute Infection within the last 2 weeks prior to the intervention
• Autoimmune diseases and immune suppressive diseases (Leukocytes < 5000/μl)
• Intake of immunomodulating drugs (Glucocorticoids, Antihistamine, ASS)
• Pregnancy, Breastfeeding, Menstruation
• Kidney insufficiency (Creatinine > 1,5 mg/dl)
• Cardiovascular diseases
• Anemia (Hb < 12g/l), disorders of wound healing or blood clotting
• Participation in another study within the last 2 months before the investigation
• Metallic or magnetic items on or in the body
• Claustrophobia
• Thyroid dysfunction
• Intake of glitazones or insulin therapy
• Smoking (Non-smoking since > 1 year), alcohol consumption (Men > 30 g/d, Women > 20g/d) or illegal drugs
• Psychiatric disorders
• Risk for/or manifest AIDS (HIV) or Hepatitis B or C
• Night shift working
• Hypersensitivity to local anesthetics
• Cancer disease
• Lung diseases
• Systematic endurance training (>1x per week > 60min.)
• Maximal oxygen consumption (VO2 max) <20ml/min/kg
• Orthopedic disorders
• Musculoskeletal diseases

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

high intensity interval training

Experimental group

Description:

30 minute sessions of high-intensity interval training on a bicycle ergometer three times per week

Treatment:

Other: High intensity interval training