Effect of Homogenization and Pasteurization of Milk on the Stomach Problems in Adults

University of Turku

Status: Completed

Conditions: Unidentified Stomach Discomfort Following Dairy Consumption

Treatments: Other: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02219126

MILK

Details and patient eligibility

About

This study aims to investigate differences in digestion rates and stomach problems caused by pasteurized and homogenized milk compared with raw milk in healthy adults by ingestible capsule that measures pH and pressure, diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Enrollment: 11 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Homogenized and pasteurized milk causes stomach problems (self-reported)
• unhomogenized and unpasteurized milk does not cause stomach problems (self-reported)
• age 18-65
• BMI 18,5 - 30
• hemoglobin under normal range
• fasting plasma alanine aminotransferase ALAT < 60 U/l (normal liver function)
• fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• fasting plasma creatinine < 118 umol/l (normal kidney function)

Exclusion criteria

• pace maker
• Crohn's disease or other disease of the intestinal tract
• intestinal operation within the last 3 months
• difficult dysphagia
• smoking
• constipation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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11 participants in 2 patient groups

Homogenized and pasteurized milk

Experimental group

Description:

Milk that has undergone homogenization ans pasteurization treatment

Treatment:

Other: Dietary intervention

Nonhomogenized and nonpasteurized milk

Experimental group

Description:

Unhomogenized and unpasteurized milk (raw milk)

Treatment:

Other: Dietary intervention