Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate. (TETHER)

Catholic University (KU) of Leuven

Status: Enrolling

Conditions: Randomized Controlled Trial; Hyaluronan-EnRiched Medium

Treatments: Other: use of hyaluronan-enriched transfer medium

Study type: Interventional

Funder types: Other

Identifiers

NCT04697823

S64387

Details and patient eligibility

About

Assessing whether the use of hyaluronan-enriched transfer medium can increase the cumulative ongoing pregnancy rate

Enrollment: 400 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with own oocytes/embryos;
• Patients with female age at 1st OR in the study <40 year;
• Patients planned for a 2nd oocyte retrieval, with no clinical ongoing pregnancy after the previous oocyte retrieval
• Patients planned for a 3rd oocyte retrieval with no clinical ongoing pregnancy after previous oocyte retrievals
• Patients with female age at 1st OR in the study <40 year;
• Patients with BMI ≤32;
• Patients with written informed consent;

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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400 participants in 2 patient groups

study group

Active Comparator group

Description:

Patients receiving an embryo transfer in hyaluronan-enriched transfer medium

Treatment:

Other: use of hyaluronan-enriched transfer medium

control group

No Intervention group

Description:

Patients receiving an embryo transfer in conventional culture medium