Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure

Osaka General Medical Center

Status and phase: Unknown; Phase 4

Conditions: Chronic Renal Failure

Treatments: Drug: N-acetylcysteine

Study type: Interventional

Funder types: Other

Identifiers

NCT00716001

OPTSB

Details and patient eligibility

About

This study is to evaluate the efficacy of sodium bicarbonate plus N-acetylcysteine for the prevention of contrast-induced nephropathy.

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with chronic renal failure(serum creatinine >1.1mg/dl) undergoing elective percutaneous coronary intervention

Exclusion criteria

• administered with sodium bicarbonate and/or N-acetylcysteine and/or contrast media within 72 hours.
• pregnancy
• congestive heart failure
• allergy to sodium bicarbonate and/or N-acetylcysteine
• hemodialysis

Trial design

0 participants in 2 patient groups, including a placebo group

NAC

Active Comparator group

Treatment:

Drug: N-acetylcysteine

nonNAC

Placebo Comparator group

Treatment:

Drug: N-acetylcysteine