Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

Cairo University (CU)

Status: Unknown

Conditions: Intussusception

Treatments: Drug: Hydrocortisone; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02691858

CAIUNIPEDSURG-CR3

Details and patient eligibility

About

Intussusception is one of the most frequent causes of acute bowel and second most common cause of acute abdominal pain in pediatric age .95 % of cases are idiopathic, the rest are either due to pathological lead point or post operative. Treatment of intussusception must start with medical resuscitation, then radiological or operative reduction of intussusception.

Our surgery team has used hydrocortisone with the medical resuscitation to improve the success rate of pneumatic reduction and decrease the number of reduction trials.

Full description

Experimental group will be given single dose IV Hydrocortisone 10 mg/kg with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Control group will be given Saline 100 ml IV single injection with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Enrollment: 80 estimated patients

Sex: All

Ages: 3 months to 4 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infantile Intussusception

Exclusion criteria

• Peritonitis Pneumoperitoneum Morbid patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

Hydrocortisone

Experimental group

Description:

Hydrocortisone IV 10 mg/kg with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction

Treatment:

Drug: Hydrocortisone

Saline

Placebo Comparator group

Description:

Saline IV 100 ml with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction

Treatment:

Drug: Saline