Effect of Hydroxycitrate on Urine Chemistry

NYU Langone Health

Status: Completed

Conditions: Nephrolithiasis

Treatments: Dietary Supplement: Hydroxycitrate (HCA)

Study type: Interventional

Funder types: Other

Identifiers

NCT03348228

17-00147

Details and patient eligibility

About

Hydroxycitrate (HCA) is a compound extracted from the fruit, Garcinia Cambogia. Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement. There has been recent evidence that hydroxycitrate is a potent inhibitor of calcium oxalate crystal growth and can lead to the dissolution of the crystals. The purpose of this research study is to study the effect of Hydroxycitrate (HCA) supplements on HCA urinary excretion and on urine chemistries in kidney stone formers and normal subjects.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Stone formers group:

• Established diagnosis of recurrent calcium stone formers
• Ages between 18 and 80
• Subjects must be able to read and follow instructions clearly and able to do 24 hour urine collections.
• Subjects must be voluntarily willing and able to sign an informed consent form.

Control Group:

• In addition to b, c and d above, subjects must not have any known kidney disease or family history of renal stones. Inclusion would be based on information provided by participants.

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups, including a placebo group

Control Group

Placebo Comparator group

Description:

Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days

Treatment:

Dietary Supplement: Hydroxycitrate (HCA)

Calcium Stone Formers

Active Comparator group

Description:

Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet. HCA will be administered afterwards to both groups (see methods below) for 7 days

Treatment:

Dietary Supplement: Hydroxycitrate (HCA)