Effect of Hyoscine and Promethazine on Labor Pain

Mashhad University of Medical Sciences

Status and phase: Completed; Phase 3; Phase 2

Conditions: Labor Pain

Treatments: Drug: Promethazine; Drug: Hyoscine

Study type: Interventional

Funder types: Other

Identifiers

NCT01644838

Hyoscine & Promethazin

Details and patient eligibility

About

It is always considered to shorten the duration of delivery without compromising the mother and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research is very limited, with conflicting results regarding the efficacy of these two drugs. So the investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor.

Enrollment: 93 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-35 yrs,
• primiparous,
• having single fetus with cephalic presentation, gestational age 37-42 weeks,
• having no medical diseases,
• having no history of hospitalization due to psychological diseases,
• having no addiction to cigarette,
• having no complications during pregnancy such as hypertension,
• BMI< 26

Exclusion criteria

• bleeding
• CPD
• use of PG or Oxytocin
• fetus distress

Trial design

93 participants in 2 patient groups

Promethazine

Experimental group

Description:

25 mg of promethazine

Treatment:

Drug: Promethazine

Hyoscine

Experimental group

Description:

20 mg of hyoscine

Treatment:

Drug: Hyoscine