Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease

St. Luke's Hospital, Chesterfield, Missouri

Status

Terminated

Conditions

Cerebral Small Vessel Diseases

Treatments

Other: hyperbaric oxygen treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT02890888

2014.011

Details and patient eligibility

About

Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.

Full description

Functional MRI studies will be done before and 4-6 weeks after Hyperbaric Oxygen treatment to assess changes in connectivity of resting state neural networks. 10 hyperbaric treatments at 2 atmospheres absolute for 1 hour at pressure will be administered. A review of symptoms and and thorough clinical neurological examination by an experienced neurologist familiar with these studies will be done before and 4-6 weeks after the hyperbaric treatments.

Enrollment

6 patients

Sex

All

Ages

50 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

White Matter Hyperintensities on MRI
2 or more neurological symptoms or impairments e.g. gait disturbances, disequilibrium, cognitive decline, dysmetria, hyper-rflexia

Exclusion criteria

Contraindication to hyperbaric oxygen treatment e.g. pulmonary emphysema, seizure disorder
major eustachian tube dysfunction
stroke with previous 6 months
extreme cognitive impairment
major depression
history of migraine, electroshock therapy, brain irradiation, brain tumor, head trauma
other uncontrolled co-morbidities, e.g. diabetes, renal or hepatic dysfunction, hypertension, thyroid disorders, carotid artery stenosis (>70%)