Effect of Hypericum Perforatum Oil on Ecchymosis and Pain

Uskudar University

Status: Completed

Conditions: Ecchymosis; Pain

Treatments: Other: Topical hypericum perforatum oil intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06367036

2021-52

Details and patient eligibility

About

Low molecular weight heparin is a drug with anticoagulant and antithrombotic effects. This drug is frequently administered subcutaneously to patients by nurses. Complications such as pain, ecchymosis and hematoma may commonly occur at the injection site. This study investigated the effect of Hypericum Perforatum oil in preventing pain and ecchymosis after subcutaneous injection low molecular weight heparin. This quasi-experimental and single blinded study was conducted with 160 patients in a coronary intensive care unit. The researcher nurse applied 5-6 drops of Hypericum Perforatum oil to one arm of the patients 2 hours before the injection. The other arm of the patient was considered as the control arm. A total of 320 injections were administered. The evaluation of the injection sites was performed by two other researchers at 48th hours. The data were analyzed using Wilcoxon and McNemar test.

Enrollment: 160 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Over 18 years of age
• Normal platelet value,
• Normal international normalised ratio (INR) and prothrombin time (PTZ) values,
• No infection, scar tissue or incision in the lateral upper arm

Exclusion criteria

• Pregnancy
• Administration of haemodialysis

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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160 participants in 2 patient groups

Hypericum Perforatum Oil group

Experimental group

Description:

This research is a self-controlled study. One injected arm of the patient will be assigned to the intervention group and the other arm to the control group. İn the experimental arm, the research nurse working in the Coronary Intensive Care unit (CICU) applied 5-6 drops of HP oil on one arm of the patient with a patting motion 2 hours before the injection. The area was left open for the oil to be absorbed. Only this nurse who administered the injection knows on which arm the oil was applied. The assessment of ecchymosis and pain at the injection site was performed by two other investigators at the 48th hour of the injection (Single blind).

Treatment:

Other: Topical hypericum perforatum oil intervention

Control group

No Intervention group

Description:

This research is a self-controlled study. One injected arm of the patient will be assigned to the intervention group and the other arm to the control group.In the control arm, no treatment was performed before injection.The assessment of ecchymosis and pain at the injection site was performed by two other investigators at the 48th hour of the injection (Single blind).