Effect of Hypocalcemia on the Outcome of Elderly Major Trauma Patients With Trauma-induced Coagulopathy

Zhejiang University

Status: Enrolling

Conditions: Coagulopathy; Trauma

Treatments: Other: hypocalcemia

Study type: Observational

Funder types: Other

Identifiers

NCT05530161

2020-822

Details and patient eligibility

About

Hypocalcaemia is an independent risk factor of TIC in elderly trauma patients. TIC combined with hypocalcemia had worse coagulation function and more serious acidosis.

Full description

This 5-year retrospective, observational, single-center study was conducted at the Second Affiliated Hospital of Zhejiang University Medical School (SAHZU, China). Elderly patients with trauma were registered when they were admitted into intensive care unit affiliated to department of Emergency medicine (EICU) since January 2015 and September 2020.The purpose of this study is to elucidate the effect of hypocalcemia on TIC in elderly trauma patients through a single-center retrospective study, so as to further optimize the diagnosis and treatment strategies for TIC in elderly trauma patients.

Enrollment: 371 estimated patients

Sex: All

Ages: 65 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age≥65 years old
• history of trauma

Exclusion criteria

• previous anticoagulants or antiplatelet medication;
• Coagulopathy caused by previous underlying diseases;
• Blood products transfused before admission;
• Cardiac arrest on admission;
• Malignant tumor;
• Data incomplete

Trial design

371 participants in 2 patient groups

trauma induced coagulopathy

Description:

patients with INR\>1.2

Treatment:

Other: hypocalcemia

non-trauma induced coagulopathy

Description:

patients with INR≤1.2