Effect of Ile-Pro-Pro (IPP) on Endothelial Function in Patients With Coronary Artery Disease
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About
This study will investigate whether the lacto-tripeptide Ile-Pro-Pro (IPP) improves the function of the endothelium in patients with coronary artery disease. The study has a crossover design. Participants will be treated with a protein hydrolysate rich in IPP for 12 weeks and placebo for 12 weeks with a four-week rest period between treatment periods. The investigators will use ultrasound to test the function of the endothelium in the brachial artery before, after 6 weeks, and after 12 weeks of each treatment. Blood will be collected before and after each treatment. The investigators hypothesize that IPP will improve endothelial function.
Enrollment
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Inclusion criteria
- Coronary artery disease
Exclusion criteria
- Treatment with an ACE inhibitor or ARB
- Pregnancy
- Other major illness
- Treatment with an investigational drug within 4 weeks
Trial design
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Interventional model
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Data sourced from clinicaltrials.gov
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