Effect of Iloprost on Pulmonary Oxygenation in Patients With Low Diffusing Capacity During One-lung Ventilation

Yonsei University

Status

Completed

Conditions

Lung Cancer

Treatments

Drug: iloprost

Drug: normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT02784899

4-2015-0706

Details and patient eligibility

About

One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, investigators are planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc).

Enrollment

40 patients

Sex

All

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

scheduled for Video-assisted thoracoscopic surgery (VATS) lobectomy
40 < age < 80
American Society of Anaesthesiologists (ASA) physical status classification I~III
diffusing capacity (DLCO) <75% at pre op. pulmonary function test

Exclusion criteria

American Society of Anaesthesiologists (ASA) physical status classification IV
New York Heart Association (NYHA) class III~IV
Severe obstructive lung disease and/or restrictive lung disease patients
patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
arrhythmia
pregnant women
disease that can influence the DLCO result (anemia, pulmonary vascular disease)