Effect of Immune-enhancing Enteral Nutrition on Immunomodulation in Critically Ill Patients

Yonsei University

Status: Completed

Conditions: Critical Illness

Treatments: Dietary Supplement: high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan; Dietary Supplement: standard enteral nutrition; Dietary Supplement: high-protein enteral nutrition of immune modulating nutrients without β-glucan

Study type: Interventional

Funder types: Other

Identifiers

NCT02569203

BT_ICU_immune

Details and patient eligibility

About

To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with standard enteral nutrition (control: 20% of total calorie from protein) or high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients without β-glucan in critically ill patients.

Full description

To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with standard enteral nutrition (control: 20% of total calorie from protein) or high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients without β-glucan in critically ill patients. In a randomized double-blind placebo-controlled study, 30 patients consumed 1 of 3 enteral nutrition: control, enteral nutrition of immune modulating nutrients enriched with β-glucan (250mg/L) or enteral nutrition of immune modulating nutrients without β-glucan. Enteral nutrition was initiated within 24 hours of ICU admission and continued during the ICU stay for a 7 days.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU patients

Exclusion criteria

• ICU patients who could not receiving enteral nutrition

Trial design

30 participants in 3 patient groups, including a placebo group

control group

Placebo Comparator group

Description:

standard enteral nutrition

Treatment:

Dietary Supplement: standard enteral nutrition

test group I

Experimental group

Description:

high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan

Treatment:

Dietary Supplement: high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan

test group II

Experimental group

Description:

high-protein enteral nutrition of immune modulating nutrients without β-glucan

Treatment:

Dietary Supplement: high-protein enteral nutrition of immune modulating nutrients without β-glucan