Effect of Increased Protein Intake on Colonic Metabolism

Catholic University (KU) of Leuven

Status: Completed

Conditions: Toxicity in the Colon; Protein Fermentation

Treatments: Dietary Supplement: High protein intake; Dietary Supplement: Low Protein intake

Study type: Interventional

Funder types: Other

Identifiers

NCT01280513

ML5174

Details and patient eligibility

About

The purpose of this study is to modulate the protein fermentation and to investigate the effect on colon toxicity.

Enrollment: 20 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Regular eating pattern (3 meals/day)
• Age between 18 and 45 years old
• BMI between 18,5 and 30 kg/m²

Exclusion criteria

• Intake of antibiotics in the last month before the study
• Abdominal surgeries in the past (accept appendectomy)
• Consulting a dietician/following a diet
• Vegetarian
• Intake of pre- and/or probiotics
• Exposure to radioactivity in the year proceeding the study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

High Protein intake

Experimental group

Treatment:

Dietary Supplement: High protein intake

Low Protein intake

Experimental group

Treatment:

Dietary Supplement: Low Protein intake