Effect of Individualized Exercise in Elderly Patients With Coronary Heart Disease

Nanjing Medical University

Status: Enrolling

Conditions: Coronary Heart Disease

Treatments: Behavioral: Individual rehabilitation exercise training; Drug: optimal medical therapy ：aspirin, clopidogrel, statins.

Study type: Interventional

Funder types: Other

Identifiers

NCT06588231

IECHD

Details and patient eligibility

About

The benefits of cardiac rehabilitation have been supported by a large amount of evidence-based medicine. Cardiac rehabilitation can correct cardiovascular risk factors, reduce morbidity and mortality, and improve quality of life.

Full description

Cardiac rehabilitation includes drug, exercise, nutrition, psychological and behavioral intervention, smoking and alcohol restriction five prescription comprehensive medical measures, so as to improve the symptoms and prognosis of patients. Cardiac rehabilitation can not only delay the progress of the disease and improve the prognosis, but also improve the physical and mental state of patients, which has been recommended by the European Cardiology Association, the American Heart Association and the American Heart Association as Class I in the treatment of cardiovascular disease. Through the comprehensive intervention of patients, their physical, psychological and social functions can be restored to the best state, which can prolong life and significantly improve the quality of life, which is the essence of modern cardiac rehabilitation. Exercise rehabilitation is the core content of cardiac rehabilitation, which refers to the use of appropriate body exercise to help patients promote physical and mental health through exercise prescription and exercise guidance on the basis of comprehensive evaluation. The realization of sports rehabilitation requires a reasonable exercise prescription, which refers to the method of prescribing patients' exercise content and amount of exercise in the form of prescription according to individual physical condition and combining with environment and preference as far as possible. The best exercise prescription should be able to comprehensively promote health-related physical fitness, that is, cardiopulmonary endurance, muscle strength and endurance, flexibility, body composition and neuromotor fitness, and should be formulated in accordance with the principles of FITTVP, including frequency (several times a week), intensity (exertion), time (duration or total time), mode (pattern or type), as well as total and progress.

Enrollment: 200 estimated patients

Sex: All

Ages: 60 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary heart disease: coronary angiography confirmed patients with coronary heart disease.
• Age is 60-75 years old, and the clinical sinus rhythm is stable.
• Left ventricular ejection fraction was> 40%.
• Informed consent and voluntary participation.

Exclusion criteria

• Patients with severe organic cardiac and lung diseases.
• Patients with hemiplegia and other physical action disorders.
• A history of mental illness.
• Uncontrolled hypertension, and hemodynamic instability.
• Severe nephropathy and severe peripheral artery disease.
• Patients with bone and joint diseases who are not suitable for exercise.
• Uncontrolled endocrine system and other diseases.
• Antibiotics and anti-diarrheal medications have not been used for at least 3 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

the control group

Active Comparator group

Description:

The patients in the control group were treated with routine rehabilitation nursing, while those in the control group were treated with routine antiplatelet drugs and lipid-lowering drugs after operation. Professional salesmen, according to the specific physical conditions of the patients, formulate corresponding recipes to ensure that the patients have a light diet, low salt, low fat and high nutritional value, and prohibit tobacco and alcohol.

Treatment:

Drug: optimal medical therapy ：aspirin, clopidogrel, statins.

the exercise group

Experimental group

Description:

The exercise group was given individualized rehabilitation training intervention on the basis of the control group. After 2 weeks of adaptive exercise training, there were no adverse events and voluntarily continued the participants. Under the guidance of the specialist, the exercise group received moderate and high intensity interval training, 3 times a week, 30-40 minutes each time, including the beginning of 5 minutes of warm-up and the last 5 minutes of cooling-off period.

Treatment:

Drug: optimal medical therapy ：aspirin, clopidogrel, statins.

Behavioral: Individual rehabilitation exercise training