Effect of Indoor Air Quality Improvement on Health in Patients With Interstitial Lung Disease

Peking Union Medical College

Status: Begins enrollment this month

Conditions: ILD

Treatments: Behavioral: Purifier (without Filter) Arm; Behavioral: Air Purifier (with Filter) Arm

Study type: Interventional

Funder types: Other

Identifiers

NCT07344987

CAMS-PUMC-IRM-IAQ-ILD-2025

Details and patient eligibility

About

Air pollution threatens the respiratory health of patients with interstitial lung disease (ILD). High-efficiency air purifiers, featuring easy operation and excellent particulate matter removal efficiency, have been shown in previous studies to potentially delay lung function deterioration and reduce acute exacerbation risk in respiratory disease patients. This randomized crossover study employs air purifiers to filter indoor gaseous pollutants, allergens, and other contaminants, aiming to alleviate respiratory irritation, improve daily life comfort, and enhance overall health status in ILD patients.

Enrollment: 100 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with interstitial lung disease (ILD).
• Stable disease status, defined as no hospitalization due to acute exacerbation within the past month.

Exclusion criteria

• Patients with complications of severe organ failure (including heart, liver, or kidney failure), malignant tumors, or mental disorders.
• A history of respiratory tract infection within the past two weeks.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

100 participants in 2 patient groups

Purifier (without Filter) Arm

Sham Comparator group

Treatment:

Behavioral: Purifier (without Filter) Arm

Air Purifier (with Filter) Arm

Experimental group

Treatment:

Behavioral: Air Purifier (with Filter) Arm