Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Zhujiang Hospital

Status and phase: Unknown; Phase 4

Conditions: Oxidative Stress; Anesthesia; Hemodynamics

Treatments: Drug: Etomidate; Drug: midazolam; Drug: Cisatracurium Besilate; Drug: Propofol; Drug: Penehyclidine Hydrochloride Injection; Drug: Remifentanil; Drug: Sevoflurane; Drug: Fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT02202239

20140723

Details and patient eligibility

About

To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 18 and 65 years;
• Diabetic patients preparing for elective surgery;
• Body mass index is between 16 and 30 kg/m2;
• Blood glucose is under 8.3 mmol/kg by oral antidiabetic agents or diet control;
• American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ;
• Expected operation duration is between 2 and 8 h;
• Signed informed consent form.

Exclusion criteria

• Severe cardiac, cerebral, liver, kidney, lung, endocrine disease or infectious disease;
• Chemotherapy or immunotherapy before the surgery;
• Allergy to trial drug or other contraindication;
• Expected or history of difficult airway;
• Suspected abuse of narcotic analgesia;
• Diseases of neuromuscular system;
• Mentally unstable or has a mental illness;
• Trend of malignant hyperthermia;
• Pregnant or breast-feeding women;
• Attendance of other trial past 30 days.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Group E

Experimental group

Description:

Etomidate was used in both induction and maintenance of anesthesia.

Treatment:

Drug: Cisatracurium Besilate

Drug: Fentanyl

Drug: Sevoflurane

Drug: Remifentanil

Drug: Penehyclidine Hydrochloride Injection

Drug: Etomidate

Drug: midazolam

Group P

Active Comparator group

Description:

Propofol was used in both induction and maintenance of anesthesia.

Treatment:

Drug: Cisatracurium Besilate

Drug: Fentanyl

Drug: Sevoflurane

Drug: Remifentanil

Drug: Propofol

Drug: midazolam