Effect of Inflammation on Pharmacokinetics of Posaconazole

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Mycoses

Treatments: Drug: posaconazole

Study type: Observational

Funder types: Other

Identifiers

NCT02492802

POSA-CRP

Details and patient eligibility

About

Posaconazole plasma concentration and inflammatory markers will be determined in all samples available from routine analysis.

Full description

A prospective observational study will be performed at the University Medical Center Groningen, the Netherlands using longitudinal data collection. The design of the study will be that patients starting on posaconazole treatment will be evaluated. After informed consent is obtained medical data will be collected from the medical chart. Posaconazole plasma concentration (trough levels) and inflammatory markers (e.g. C-reactive protein) will be determined in all samples available from routine analysis (often daily). This will result in a detailed data set capturing day to day variations in inflammation and drug concentrations.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >18 yrs
• receiving posaconazole
• Written informed consent

Exclusion criteria

• none

Trial design

64 participants in 1 patient group

posaconazole-group

Description:

patients receiving posaconazole for prophylaxis or treatment of invasive fungal infection

Treatment:

Drug: posaconazole