Effect of Inflammation on Voriconazole Concentration

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Fungal Infection; Inflammation

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02074462

VCZ-13O30

Details and patient eligibility

About

Voriconazole is a broad-spectrum antifungal agent. There is evidence for a relation between the efficacy and safety of voriconazole and voriconazole trough concentrations. There are several factors that could influence voriconazole concentrations. Inflammation could be one of these factors. In a retrospective study was observed that reduced metabolism of voriconazole was related to inflammation in patients with severe infections. Reduced metabolism of voriconazole resulted in high voriconazole levels and low N-oxide metabolite (inactive metabolite of voriconazole) levels. The purpose of this study is to determine an algorithm to guide dosing of voriconazole during severe inflammation and to develop a multiple linear regression model to describe the contribution of CRP concentrations to the variability in voriconazole levels and metabolic ratio.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 yrs
• treatment with voriconazole
• written informed consent

Exclusion criteria

• concomitantly using a strong inhibitor or inducer of CYP P450