Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome Course

Moscow Regional Research and Clinical Institute (MONIKI)

Status and phase: Unknown; Phase 4

Conditions: ARDS

Treatments: Drug: Intravenous Sedation; Drug: Inhalation Sedation

Study type: Interventional

Funder types: Other

Identifiers

NCT04014218

SS2019

Details and patient eligibility

About

Investigation of effect of inhalation sedation by administration of Sevoflurane compared with Propofol on the moderate acute respiratory distress syndrome course in mechanically ventilated patients with sepsis.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sepsis
• ARDS
• P/F Ratio 100-250
• start of mechanical ventilation

Exclusion criteria

• pregnancy
• concomitant oncological disease
• prior psychological impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Inhalation sedation

Experimental group

Treatment:

Drug: Inhalation Sedation

Propofol

Active Comparator group

Treatment:

Drug: Intravenous Sedation