Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study)

Assistance Publique - Hôpitaux de Paris

Status and phase: Completed; Phase 3; Phase 2

Conditions: Sickle Cell Disease; Acute Chest Syndrome

Treatments: Drug: Placebo; Drug: Nitric Oxide

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00748423

P060701

Details and patient eligibility

About

Acute chest syndrome (ACS) is a frequent and potentially life-threatening pulmonary illness. It is a complication of sickle cell disease and is the leading cause of death from this disease in adults. Several pathologic processes are recognized causes of ACS, including infectious diseases, hypoventilation secondary to chest pain, in situ thrombosis and pulmonary fat embolism. Inhaled nitric oxide (iNO) has been shown to be a pulmonary vasodilatator with minimal systemic effects and has also been shown to improve gas exchange in both animal and human acute lung injury (ALI).

The combined effects of iNO gas of improving pulmonary ventilation to perfusion matching, reducing alveolar and systemic inflammation, modulate the course of acute chest syndrome, which combine the physiopathology of vaso-occlusive crisis and acute lung injury.

We hypothesise inhaled NO will improve oxygenation and clinical outcome of sickle cell disease patients with acute chest syndrome.

Full description

Objectives: To compare the outcome and duration of acute chest syndrome (ACS) in patients with sickle cell disease (SCD) treated with iNO to that of similar episodes experienced by patients which receive a placebo.

Study design: Bi-center, prospective, randomized, controlled clinical trial

• Enrollment: 24 months
• Patients will be treated for 72 hours
• Patients will be followed for 15 days or until discharged home

Sample size:

• The study will accrue a maximum of 240 patients
• Progress of the trial will be reviewed by an independent data and safety monitoring committee to determine if randomization should stop for safety reasons.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with sickle cell disease (Hemoglobin genotypes characterized by standard procedures as homozygous hemoglobin SS, hemoglobin SC, and S beta thalassemia)
• Diagnosis of acute chest syndrome based on the presence of fever, dyspnea or chest pain, associated with new pulmonary infiltrates on chest X-ray

Exclusion criteria

• Patient has been hospitalised < 14 days ago

• Patients presenting with clinically diagnosed bacterial infections

• Patients who have received an exchange transfusion in the last 30 days or are in a transfusion program.

• Current pregnancy or lactation

• Patient who is currently enrolled in any other investigational drug study

• Previous participation in this study

• Any of the following medical conditions:

  • Immediate need of ventilatory support wih orotracheal intubation
  • Hemodynamic instability

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

Nitric Oxide in nitrogen

Treatment:

Drug: Nitric Oxide

2

Placebo Comparator group

Description:

Nitrogen

Treatment:

Drug: Placebo