Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: PEEP, Occult; ARDS, Human; Esophageal and Pleural Pressure

Treatments: Other: PEEP adjustment

Study type: Observational

Funder types: Other

Identifiers

NCT05442073

ZS-2458

Details and patient eligibility

About

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes<30%ΔPEEP）.

Enrollment: 18 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation

Exclusion criteria

• aged<18 contraindication to esophageal catheter

Trial design

18 participants in 2 patient groups

Type I: ΔPes≥30%ΔPEEP

Treatment:

Other: PEEP adjustment

Type II: ΔPes<30%ΔPEEP

Treatment:

Other: PEEP adjustment