Effect of Injectable Platelet-rich Fibrin on Disc Displacement Without Reduction

Ege University

Status: Completed

Conditions: Disc Disorder

Treatments: Procedure: Arthrocentesis; Procedure: i-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT05640206

22038

Details and patient eligibility

About

This randomized clinical study was conducted on patients with disc displacement without reduction. Patient was selected one of the two study groups: control group received only arthrocentesis or test group received arthrocentesis + injectable platelet-rich fibrin (i-PRF). As primary outcome variable, pain was recorded at preoperatively and at postoperatively 1, 2, 3, 6 and 12 months. Maximum mouth opening, lateral and protrusive movements were formed as secondary outcome variables.

Full description

This randomized clinical study was conducted on patients with disc displacement without reduction. Patient was selected one of the two study groups: control group received only arthrocentesis or test group received arthrocentesis + i-PRF. Arthrocentesis procedure was performed for all groups with two needle technique. For test group, intra-articular i-PRF was made. As a primary outcome variable, pain was recorded at preoperatively and at postoperatively 1, 2, 3, 6 and 12 months. Maximum mouth opening, lateral and protrusive movements were formed as secondary outcome variables.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• unilateral or bilateral disc displacement without reduction
• localized pain on temporomandibular joint
• decreased mouth opening, lateral and protrusive movements

Exclusion criteria

• Malignant or inflammatory disorders
• prior surgical history of temporomandibular joint

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Test group

Experimental group

Description:

intra-articular i-PRF injection after arthrocentesis

Treatment:

Procedure: i-PRF

Control group

Experimental group

Description:

only arthrocentesis

Treatment:

Procedure: Arthrocentesis