Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis

Beni-Suef University

Status: Completed

Conditions: Hemodialysis; Glomerular Filtration Rate; Blood Flow Restriction Training; Quality of Life

Treatments: Other: blood flow restriction training; Other: conventional exercise Program

Study type: Interventional

Funder types: Other

Identifiers

NCT06976281

Alaa-02012024

Details and patient eligibility

About

this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis

Full description

Chronic kidney disease affects 10% to 15% of the population and is characterized by a progressive decline in glomerular filtration rate. The disease can lead to frailty, muscle mass wasting, and sarcopenia, affecting functional mobility and quality-of-life measures. The increased protein catabolism in Chronic kidney disease is partly due to inflammatory status, nutrient loss during dialysis, and musculoskeletal system changes. Assessment of muscle functionality can provide additional diagnostic and prognostic information for clinical outcomes, quality of life, and mortality rates. Exercise training with blood flow restriction is a potential method for clinical musculoskeletal rehabilitation, potentially improving strength, physical function, blood pressure control, glucose homeostasis, autonomic function, renal deterioration, dialysis adequacy, and antioxidant defenses.

Enrollment: 30 patients

Sex: All

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients were

1. Both sex aged from forty to sixty years
2. Stable chronic hemodialysis patient (< 3 months)
3. Participants will be deemed medically eligible by their treating physician before participation in the present study
4. Free from any other disease could interfere with exercise

Exclusion criteria

1. Hemodynamic instability during hemodialysis over the last month
2. Neurodegenerative diseases
3. Autoimmune diseases (i.e., lupus erythematosus)
4. Surgery within the past 3 months
5. Severe arrhythmia, angina or cerebrovascular disease
6. Unstable on dialysis
7. Any musculoskeletal problem interfere with exercise

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

blood flow restriction

Experimental group

Description:

Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion Pressure. training was conducted for 2 time/weak for 2 consecutive month

Treatment:

Other: conventional exercise Program

Other: blood flow restriction training

conventional exercise Program

Active Comparator group

Description:

Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program only included isometric, aerobic, and resisted exercise individualized for every patient. training was conducted for 2 time/weak for 2 consecutive month

Treatment:

Other: conventional exercise Program