Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition (NARKOREX)

Zentrum für Integrative Psychiatrie

Status: Unknown

Conditions: Narcolepsy

Treatments: Drug: Orexine A

Study type: Interventional

Funder types: Other

Identifiers

NCT00484757

DFG-SFB654/C5-Narkorex

Narkorex

Details and patient eligibility

About

15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A and approximately two weeks later placebo or vice versa. Thereafter sleep will be recorded, the cytokine-system and neurocognition characterized.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Narcolepsy
• Age >18
• Informed consent
• GERMAN fluently spoken

Exclusion criteria

• Additional severe psychiatric or somatic disorders
• Pregnancy or nursing
• Anemia (Hb<10g/dl)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind