Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction

Minia University

Status: Unknown

Conditions: Middle Aged Patients

Treatments: Drug: Intranasal insulin

Study type: Observational

Funder types: Other

Identifiers

NCT04154449

164: 2/2019

Details and patient eligibility

About

Our study is designed to evaluate the effect of intranasal insulin on postoperative cognitive dysfunction.

Primary outcome:

1. The occurrence of cognitive dysfunction at approximately 7 days after surgery.

Secondary outcome:

1. Incidence of any side effect.

Enrollment: 57 estimated patients

Sex: All

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age 40 - 60 years.
2. Both gender.
3. Patients will be scheduled for elective major abdominal, thoracic, orthopedic, open gynecological, open urological, spine, otolaryngological surgeries under general anesthesia with expected hospital stay >4 days.

Exclusion criteria

• 1. Drug allergy. 2. Patients with major psychiatric disease. 3. Patients receive major tranquillizers and antidepressant. 4. Those undergoing neurosurgery or cardiac surgery. 5. Those unable or unwilling to abide by the study procedure 6. Those who could not follow procedure or who had poor comprehension of dutch language. 7. Those with sever visual and auditory disorder / handicaps.

Trial design

57 participants in 3 patient groups

Control group.

Surgical group Received intranasal insulin.

Treatment:

Drug: Intranasal insulin

Surgical group Received placebo.