Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery

Seoul National University

Status: Not yet enrolling

Conditions: Sleep Disturbance

Treatments: Drug: Dexamethasone; Drug: Normal Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT07550803

2601-116-1712

Details and patient eligibility

About

This study aims to evaluate the effect of intraoperative dexamethasone on early postoperative sleep quality in adult patients undergoing nasal surgery under general anesthesia.

Enrollment: 102 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 19 years or older undergoing nasal surgery.

Exclusion criteria

• Patients who do not provide informed consent
• Patients with neurological disease or cognitive impairment that may interfere with questionnaire completion
• Patients with pre-existing sleep disorders or those taking sleep medications
• Patients receiving chronic corticosteroid therapy
• Known hypersensitivity to dexamethasone
• Patients with glaucoma
• Patients with poorly controlled diabetes mellitus (HbA1c > 8.0%)
• Patients with peptic ulcer disease
• Pregnant or breastfeeding women
• Patients deemed unsuitable for the study by the investigator (e.g., those requiring postoperative steroid administration for clinical reasons)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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102 participants in 2 patient groups, including a placebo group

dexamethasone

Experimental group

Description:

Participants in this group will receive intravenous dexamethasone 10 mg during induction of general anesthesia. All other perioperative management, including anesthetic technique and postoperative care, will be conducted according to standard institutional protocols and will be identical to the control group.

Treatment:

Drug: Dexamethasone

placebo

Placebo Comparator group

Description:

Participants in this group will receive intravenous normal saline (2 mL) during induction of general anesthesia as a placebo. All other perioperative management, including anesthetic technique and postoperative care, will be identical to the experimental group.

Treatment:

Drug: Normal Saline