Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery

Assiut University

Status: Unknown

Conditions: Postoperative Analgesia

Treatments: Drug: Ketamine Hydrochloride; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03344393

17200147

Details and patient eligibility

About

.The aim of this study is to identify the analgesic effect of intraoperative ketamine intravenous infusion on patients undergoing intestinal surgery and its effect on salivary cortisol and alpha amylase levels as indicator of its effect.

Full description

I- Group K (ketamine): 30 patients will receive intraoperative intravenous ketamine infusion.

II- Group C (control): 30 patients will receive intraoperative intravenous normal saline infusion.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Patient's status ASA status-I and II.
• Patients age above 18 years old.
• Patients scheduled for intestinal surgery.

Exclusion criteria

• Patient refusal.
• Patients with known allergy to ketamine or morphine.
• Patients with significant hepatic dysfunction.
• Patients with severe renal disease.
• Significant Heart disease.
• Patients with chronic pain.
• Regular use analgesics, antidepressants or opioids in last 2 months.
• Any known convulsive disorder.
• Morbid obesity (BMI>35).
• Patients with autoimmune disease
• Patients on corticosteroid therapy
• Pregnancy.
• Breast feeding.
• Woman under hormonal treatment.
• Oral disease.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

ketamine hydrochloride

Active Comparator group

Description:

intravenous ketamine infusion in the intraoperative period

Treatment:

Drug: Ketamine Hydrochloride

normal saline

Active Comparator group

Description:

intravenous normal saline infusion in the intraoperative period

Treatment:

Drug: Normal saline