Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Hyperalgesia

Treatments: Drug: remifentanil, MgSO4

Study type: Interventional

Funder types: Other

Identifiers

NCT01025245

4-2009-0511

Details and patient eligibility

About

The purpose of this study is to study the effect of intraoperative magnesium on remifentanil-induced postoperative hyperalgesia after thyroidectomy

Enrollment: 84 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing thyroidectomy,
• Age 20-65,
• American Society of Anesthesiologists physical status classification I or II.

Exclusion criteria

• History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs,
• History of drug & alcohol abuse,
• Psychiatric disorder,
• Use of opioids within 24hrs,
• Renal disease with decreased GFR,
• Neuromuscular disease, Severe cardiac disease.

Trial design

84 participants in 1 patient group

remifentanil, MgSO4

Experimental group

Description:

Experimental 1 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and MgSO4 30 mg/kg IV at the induction followed by intraoperative infusion at 10 mg/kg/hr Drug : remifentanil, MgSO4 Experimental 2 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and normal saline Drug : remifentanil Active comparator : Intraoperative remifentanil infusion at 0.05 ㎍/㎏/min and normal saline Drug : remifentanil

Treatment:

Drug: remifentanil, MgSO4