Effect of Intraoperative Muscle Relaxation Depth on Postoperative Sore Throat and Hoarseness After General Anesthesia

Seoul National University

Status: Unknown

Conditions: Sore Throat

Treatments: Drug: Rocuronium(deep); Drug: Rocuronium(moderate)

Study type: Interventional

Funder types: Other

Identifiers

NCT03391700

20170601/10-2017-4/071

Details and patient eligibility

About

Investigators assess and compare postoperative sore throat and hoarseness in the group maintaining moderate relaxation and deep relaxation during operation.

Full description

In this sturdy, the deep block is applied when the surgeon requests for deep muscle relaxation to improve surgical field condition in the surgery such as laparotomy known that the deep block is helpful and in the other surgeries, the moderate block is maintained. The investigators assess the postoperative sore throat and hoarseness and compare the effect of muscle relaxation depth in the deep block group and moderate block group in terms of the incidence and severity of postoperative sore throat and hoarseness.

Enrollment: 206 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Requirement for mechanical ventilation under general anesthesia

Exclusion criteria

• Hoarseness and sore throat existed before surgery
• Upper respiratory infection
• Known or predicted difficult airway
• Liver, renal disease
• Requirement of postoperative ventilator care
• the operation within 2hrs
• Laparoscopic surgery
• Other positions except supine during surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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206 participants in 2 patient groups

Moderate muscle relaxation

Active Comparator group

Description:

Rocuronium is administered to maintain moderate relaxation during operation. This is conventional muscle relaxation level of this institute.

Treatment:

Drug: Rocuronium(moderate)

Deep muscle relaxation

Experimental group

Description:

Rocuronium is administered to maintain deep relaxation during operation.

Treatment:

Drug: Rocuronium(deep)