Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Kangbuk Samsung Hospital

Status: Completed

Conditions: Colorectal Cancer

Treatments: Drug: Lidocaine; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01346917

KHO10-1

Details and patient eligibility

About

The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer.

• Degree of nausea/vomiting.
• Degree of postoperative pain and opioids requirement.
• Time to first flatus, time to first stool, time to tolerance of regular diet, rate of postoperative complications and duration of postoperative hospital stay.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective laparoscopic colorectal surgery for colorectal cancer.
• Age > 18 years.
• Informed consent.

Exclusion criteria

• Allergy to local anesthetics.
• Severe cardiovascular, hepatic, or renal diseases.
• Pregnant or lactating patients.
• Emergency surgery.
• American Society of Anesthesiologists (ASA) class IV

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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77 participants in 2 patient groups, including a placebo group

Lidocaine

Experimental group

Treatment:

Drug: Lidocaine

Placebo

Placebo Comparator group

Treatment:

Drug: Normal saline