Effect of Intravenous Low-Dose Ketamine Infusion With Intravenous Lignocaine Infusion on Post-Operative Pain in Patients Undergoing Laparoscopic Choleysystectomy Under General Anesthesia

Fazaia Ruth Pfau Medical College

Status and phase: Completed; Phase 4

Conditions: Cholelithiases

Treatments: Drug: Intravenous lignocaine; Drug: Intravenous Ketamine Infusions

Study type: Interventional

Funder types: Other

Identifiers

NCT06964555

FRPMC-IRB-2024-41

Details and patient eligibility

About

Objective: To determine the effect of low-dose ketamine versus lignocaine on post-operative pain in patients undergoing LC under general anesthesia in a tertiary care hospital.

Sample Selection: Patients of both the gender of age at least 18 years, planned for elective LC with ASA grade I-II were included. Patients with obesity, history of alcohol consumptions, drug abusers, uncontrolled hypertension and diabetics, with chronic pain, allergic to study drugs, having neurological disorders, unable to understand pain scoring system and converted to open LC were excluded.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of both the gender of age at least 18 years
• Patients planned for elective LC
• Patients with ASA grade I-II were included.

Exclusion criteria

• Patients with obesity,
• Patients with history of alcohol consumptions, uncontrolled hypertension and diabetics,
• Drug abusers
• Patients with chronic pain
• Patients allergic to study drugs
• Patients having neurological disorders or unable to understand pain scoring system
• Patients converted to open LC

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

100 participants in 2 patient groups

Group L

Active Comparator group

Description:

Just before the skin incision intravenous lignocaine was given.

Treatment:

Drug: Intravenous lignocaine

Group K

Experimental group

Description:

Just before the skin incision, intravenous ketamine was given

Treatment:

Drug: Intravenous Ketamine Infusions