Effect of Intravenous Vitamin C on SOFA Score Among Septic Patients

University of Indonesia (UI)

Status: Completed

Conditions: Sepsis

Treatments: Drug: vitamin C, vitamin B1; Drug: vitamin B1

Study type: Interventional

Funder types: Other

Identifiers

NCT04137276

IndonesiaUAnes 39

Details and patient eligibility

About

This study aimed to explore the effect of intravenous (IV) vitamin C on sequential organ failure assessment (SOFA) score among septic patients in intensive care unit (ICU).

Full description

"This study was approved by the Ethics and Research Committee of Universitas Indonesia. This study was a randomized clinical trial held from April to July 2019 in Cipto Mangunkusumo Hospital. 33 patients that met the inclusion criteria were included in the study. Subjects were divided into two groups: group A (intervention group, n = 18) received parenteral infusions of 1,5 g/6 hours of vitamin C and 200 mg thiamine, while group B (control group, n = 15) received 200 mg thiamine only. baseline demographic data was recorded on the first day. SOFA score was recorded at baseline, 24 hours, 48 hours, and 72 hours after treatment. Data were analyzed using SPSS (Statistical Package for Social Sciences) software."

Enrollment: 33 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with sepsis diagnosis based on sepsis-3 criteria in the ICU in between 6 hours to 24 hours post resuscitation after sepsis diagnosis

Exclusion criteria

• patients with chronic kidney problems on haemodialysis,
• patients with kidney stones or kidney problem within the last 3 months

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 2 patient groups

vitamin C and thiamine

Experimental group

Description:

patients who received intravenous vitamin C and thiamine

Treatment:

Drug: vitamin C, vitamin B1

thiamine

Active Comparator group

Description:

patients who received thiamine

Treatment:

Drug: vitamin B1